In the following study, researchers investigate the cytotoxic effects of silver nitrate on A549 cells. MTT assay, flow cytometry, immunocytochemical, confocal and transmission electron microscopy, and microarray assays were used to analyze the effects of silver nitrate. Results show that silver nitrate exhibit inhibitory effects against A549 cells in a dose- and time-dependent manner, ultimately inducing apoptosis. These results suggest that silver nitrate may be used as an effective therapeutic agent against lung cancer. [LINK]
Having been studied extensively over the past few decades, A549 cells have become one of the major players in the lung carcinoma field. With numerous applications in cell signaling studies and cancer oncogene evaluations, A549 xenografts have become prime targets for transfection experiments and related research. The cells are set apart by their ability to synthesize lecithin and their internal environment; a high level of unsaturated fatty acids that contribute to the maintenance of membrane phospholipids in lung epithelial cells. The cell line has been used extensively as an in vitro host capable of receiving nucleic acids and responding effectively in drug metabolism studies.
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