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Side Population Cells Present in A549 Cells

In the following study, researchers isolate and characterize side population (SP) cells that are present in the A549 cancer cell line. Fluorescence-activated cell sorting, assays, and a chemoresistance analysis were used to isolate and differentiate SP and non-SP (NSP) cells. Results show that SP cells account for 1.09% of live A549 cells and produced both SP and NSP cells. SP cells also exhibited improved invasive ability and had higher levels of chemoresistance compared to NSP cells in vitro. Therefore, SP cells isolated from the A549 cell line exhibited more tumorigenicity, along with invasive ability and chemoresistance, than NSP cells. [LINK]


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