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Evodiamine Triggers Apoptosis in A549 Cells

Metadherin (MTDH) is a novel oncoprotein that promotes the survival and proliferation of lung cancer cells when over-expressed. In this study, researchers use staining assays and Western blotting analysis to investigate the anti-tumor effect of evodiamine in A549 cells, as well as its inhibitory effect on the MTDH pathway. Results show that evodiamine inhibits A549 cells by increasing the expression of proapoptotic protein Bax and therefore inducing apoptosis. Evodiamine consequently suppresses the proliferation of A549 cells through the inhibition of MTDH expression and induction of apoptosis. [LINK]


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